Two academic groups and eight SMEs who all work on different aspects of protein engineering will collaborate and produce a website that will consist of a portal with an embedded workbench to provide users a self-service system for in silico protein engineering. This interactive self-service portal will give users access to a wide variety of protein engineering facilities and information systems, and will allow them to interactively work with a comprehensive set of well-documented, well-integrated computational protein engineering tools. The databases that will be provided will be curated, and the software and protocols will be validated by performing a variety of protein engineering experiments on a series of enzyme classes. The portal and the interactive workbench will be freely available, and they will be solidly based in modern information technology. The usability for protein engineering will be thoroughly experimentally validated.